PHOTOREGULATION OF BIOLOGICAL ACTIVITY BY PHOTOCROMIC REAGENTS, II. INHIBITORS OF ACETYLCHOLINESTERASE
نویسندگان
چکیده
منابع مشابه
Photoregulation of biological activity by photochromic reagents, IV. A model for diurnal variation of enzymic activity.
Levels of acetylcholinesterase activity can be made to vary in response to the presence or absence of sunlight in a system that can be considered as a model for photoperiodic processes found in nature. The enzyme is rendered photosensitive by the presence of a photochromic inhibitor, N-p-phenylazophenylcarbamyl choline, which changes from a trans to a cis isomer under the influence of the light...
متن کاملIndolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling.
A series of indolinone-based compounds bearing benzylpyridinium moiety was designed as dual-binding inhibitors of acetylcholinesterase (AChE). The target compounds 3a-u were synthesized by condensation of oxindole and pyridin-4-carbalehyde, and subsequent N-benzylation. The anti-cholinesterase activity evaluation of synthesized compounds revealed that most of them had very potent inhibitory act...
متن کاملPhotoregulation of cholinesterase activity
Abszrucz: The study of the functioning of cholinesterases and in particular the identification of the clearance of enzymatic products from the active site, is undertaken by two different photoregulatory methodologies. A mechanism-based photo-inactivation of the cholinesterases is proposed to map this route of clearance. The use of radiolabeled probes will permit to identify the modified amino a...
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15 صفحه اولcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1969
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.64.3.1103